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date: Fri, 12 Sep 2008 16:47:33 +0100,    group: uk.politics.drugs        back       
JCP: Impact of Cannabis and Other Drugs on Age at Onset of Psychosis   
This article has been mentioned several times in the press. However, only
the results for cannabis are shown, which is rather odd. The whole article
is available to subscribers, is there a subscriber out there?

http://www.psychiatrist.com/abstracts/abstracts.asp?abstract=200808/080802.htm

-- 
Dr John Watson
Baker Street
date: Fri, 12 Sep 2008 16:47:33 +0100   author:   Dr John Watson

Re: JCP: Impact of Cannabis and Other Drugs on Age at Onset of Psychosis   
> This article has been mentioned several times in the press. However, only
> the results for cannabis are shown, which is rather odd. The whole article
> is available to subscribers, is there a subscriber out there?
> http://www.psychiatrist.com/abstracts/abstracts.asp?abstract=200808/080802.htm

This might help you gain access:

http://ipb.quicksilverscreen.com/index.php?showtopic=29115

"disguise yourself as google bot"
date: Fri, 12 Sep 2008 22:47:33 +0100   author:   Colin Wilson

Re: JCP: Impact of Cannabis and Other Drugs on Age at Onset of Psychosis   
Dr John Watson wrote:
> This article has been mentioned several times in the press. However, only
> the results for cannabis are shown, which is rather odd. The whole article
> is available to subscribers, is there a subscriber out there?

I've got access but wouldn't want to C+P the full text as they obviously 
want you to pay for it. If you want anything cleared up, I'd be pleased to 
check for you.

The study was to look at whether cannabis use, abuse and 
dependance decreases the age of onset of psychosis resulting in a hospital 
visit. They take into account other drug use (to ensure that wasn't the 
cause) but it was specifically a study into cannabis which is why they 
only mention cannabis.

In fact they say this in the study:

"When including these variables [other drug use] in turn together with 
cannabis use to analyze the presence of mediating variables between 
cannabis use and age at onset, we found that none of these variables 
or gender could be considered as a mediating factor because none of 
them remained significant when including cannabis use, whereas cannabis 
use always remained significant."
date: Mon, 15 Sep 2008 10:20:40 +0000 (UTC)   author:   Ollie Clark

Re: JCP: Impact of Cannabis and Other Drugs on Age at Onset of Psychosis   
Noticed at Mon, 15 Sep 2008 10:20:40 +0000: Ollie Clark informed us:

> Dr John Watson wrote:
>> This article has been mentioned several times in the press. However, only
>> the results for cannabis are shown, which is rather odd. The whole article
>> is available to subscribers, is there a subscriber out there?
> 
> I've got access but wouldn't want to C+P the full text as they obviously 
> want you to pay for it. If you want anything cleared up, I'd be pleased to 
> check for you.
> 
> The study was to look at whether cannabis use, abuse and 
> dependance decreases the age of onset of psychosis resulting in a hospital 
> visit. They take into account other drug use (to ensure that wasn't the 
> cause) but it was specifically a study into cannabis which is why they 
> only mention cannabis.

Thanks for clarifying that - the title is a bit misleading.

> 
> In fact they say this in the study:
> 
> "When including these variables [other drug use] in turn together with 
> cannabis use to analyze the presence of mediating variables between 
> cannabis use and age at onset, we found that none of these variables 
> or gender could be considered as a mediating factor because none of 
> them remained significant when including cannabis use, whereas cannabis 
> use always remained significant."

Does this include alcohol?

I do think it likely that cannabis use in developing brains would cause
any underlying problems to emerge. This would explain why cannabis is
linked to psychosis but the rate hasn't changed - the person would have
developed the illness anyway.

Of course, with cannabis being illegal the age of consumers cannot be
controlled.

-- 
Dr John Watson
Baker Street
date: Wed, 17 Sep 2008 10:38:01 +0100   author:   Dr John Watson

Re: JCP: Impact of Cannabis and Other Drugs on Age at Onset of Psychosis   
Dr John Watson wrote:
> Noticed at Mon, 15 Sep 2008 10:20:40 +0000: Ollie Clark informed us:
>
>> Dr John Watson wrote:
>>> This article has been mentioned several times in the press. However, only
>>> the results for cannabis are shown, which is rather odd. The whole article
>>> is available to subscribers, is there a subscriber out there?
>> 
>> I've got access but wouldn't want to C+P the full text as they obviously 
>> want you to pay for it. If you want anything cleared up, I'd be pleased to 
>> check for you.
>> 
>> The study was to look at whether cannabis use, abuse and 
>> dependance decreases the age of onset of psychosis resulting in a hospital 
>> visit. They take into account other drug use (to ensure that wasn't the 
>> cause) but it was specifically a study into cannabis which is why they 
>> only mention cannabis.
>
> Thanks for clarifying that - the title is a bit misleading.

Actually, having re-read it they do actually look at other drugs but 
discover they don't have an effect when you include cannabis.

>> In fact they say this in the study:
>> 
>> "When including these variables [other drug use] in turn together with 
>> cannabis use to analyze the presence of mediating variables between 
>> cannabis use and age at onset, we found that none of these variables 
>> or gender could be considered as a mediating factor because none of 
>> them remained significant when including cannabis use, whereas cannabis 
>> use always remained significant."
>
> Does this include alcohol?

"Regarding the individual contributions of each drug used (tobacco, 
alcohol, amphetamines, cocaine, and/or MDMA) on age at onset, we found 
that tobacco (log-rank test score = 10.6, p = .001, HR = 2.06), alcohol 
(log-rank test score = 5.5, p = .019, HR = 1.52), and amphetamines 
(log-rank test score = 8.88, p = .003, HR = 1.94) had an apparent 
significant effect, whereas cocaine (log-rank test score = 1.1, 
p = .303) and MDMA (log-rank test score = 3.7, p = .056) did not. 
However, these results should be considered with caution because of the 
possible presence of confounding factors. When including these variables 
in turn together with cannabis use to analyze the presence of mediating 
variables between cannabis use and age at onset, we found that none of 
these variables or gender could be considered as a mediating factor 
because none of them remained significant when including cannabis use, 
whereas cannabis use always remained significant (Table 3). Only gender 
and tobacco seemed to be close to significance (p = .096 and p = .091, 
respectively) in the whole sample, so these variables were candidates to 
be included in the multivariate model."

> I do think it likely that cannabis use in developing brains would cause
> any underlying problems to emerge. This would explain why cannabis is
> linked to psychosis but the rate hasn't changed - the person would have
> developed the illness anyway.

That seems to be a reasonable conclusion.
date: Thu, 18 Sep 2008 09:33:28 +0000 (UTC)   author:   Ollie Clark

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